COPD

COPD Pathogenesis

Chronic obstructive pulmonary (COPD) disease is that chronic airflow limitation results from an abnormal inflammatory response to inhaled particles and gases in the lung. Pathologic changes in COPD occur in the generous airways, the small bronchioles, and the lung parenchyma. The pathogenic mechanisms are not clear but are most likely diverse. Increased number of activated polymorph nuclear leukocytes and macrophages release elastases in a manner that cannot be counteracted effectively by antiproteases, emerge in lung desolation

• Chronic bronchitis
• Emphysema
• Refractory asthma

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